The first enantiospecific total synthesis of (+)-seychellene

Srikrishna, A. ; Ravi, G. ; Satyanarayana, G. (2007) The first enantiospecific total synthesis of (+)-seychellene Tetrahedron Letters, 48 (1). pp. 73-76. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2006.11.011

Abstract

The first enantiospecific total synthesis of the tricyclic sesquiterpene (+)-seychellene, starting from (R)-carvone via (S)-3-methylcarvone, has been accomplished employing a combination of an intermolecular Michael addition-intramolecular Michael addition sequence and an intramolecular alkylation reaction for the generation of the two vicinal quaternary carbon atoms.

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