Joshi, Bindu ; Biswas, Sukla ; Sharma, Yagya D. (1992) Effect of heat-shock on Plasmodium falciparum viability, growth and expression of the heat-shock protein 'PFHSP70-I' gene FEBS Letters, 312 (1). pp. 91-94. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(92)81417-K
Abstract
Cultures of the human malaria parasite Plasmodium falciparum were subjected to heat-shock for varying times and temperatures and then tested for their viability, growth and expression of heat-shock protein. Results show that the majority of parasites remained viable after heat-shock but their growth was affected. However, the expression of the heat-shock protein 'PFHSP70-I' gene was enhanced after heat-shock. We conclude that malarial parasites are able to survive in vivo during fever probably due to the overexpression of the heat-shock protein gene.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Heat-shock Protein; Gene Expression; Human Malaria Parasite; Fever |
| ID Code: | 48641 |
| Deposited On: | 15 Jul 2011 07:53 |
| Last Modified: | 15 Jul 2011 07:53 |
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