Reddy, Raju C. ; Vatsala, Palakkodu G. ; Keshamouni, Venkateshwar G. ; Padmanaban, Govindarajan ; Rangarajan, Pundi N. (2005) Curcumin for malaria therapy Biochemical and Biophysical Research Communications, 326 (2). pp. 472-474. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...
Related URL: http://dx.doi.org/10.1016/j.bbrc.2004.11.051
Abstract
Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant Plasmodium falciparum growth in culture in a dose dependent manner with an IC50 of ~5 μM. Additionally, oral administration of curcumin to mice infected with malaria parasite (Plasmodium berghei) reduces blood parasitemia by 80-90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Curcumin; Malaria; Plasmodium; Artemisinin |
| ID Code: | 34374 |
| Deposited On: | 18 Apr 2011 14:11 |
| Last Modified: | 05 Jul 2012 09:37 |
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