Mazumder, Shibnath ; Indira Nath, ; Dhar, M. M. (1993) Immunomodulation of human T cell responses with receptor selective enkephalins Immunology Letters, 35 (1). pp. 33-38. ISSN 0165-2478
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/016524...
Related URL: http://dx.doi.org/10.1016/0165-2478(93)90144-Q
Abstract
The δ-opioid receptor selective [2-d-penicillamine-5-d-penicillamine] enkephalin (DPDPE) and the μ receptor selective Tyr-d-Orn-Phe-As p-NH2 (TOPA) were found respectively, to have marked immunostimulant and immunosuppressant activities in both normal subjects and patients suffering from leprosy and tuberculosis. Antigen specific lymphoproliferation and numbers of rosette forming T cells were significantly (P <0.05) enhanced on in vitro treatment with Met-enkephalin. This was further increased (P <0.001) in the presence of the d selective DPDPE. In contrast, treatment with μ selective TOPA inhibited lymphoproliferation substantially (P <0.01) and rosette formation to a lesser extent.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Immunomodulation; δ and μ Opioid Receptor Selective Enkephalins; Leprosy; Tuberculosis |
| ID Code: | 27604 |
| Deposited On: | 10 Dec 2010 11:59 |
| Last Modified: | 02 Jun 2011 11:52 |
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