Das, K. ; Jain, B. ; Dube, A. ; Gupta, P. K. (2005) pH dependent binding of chlorin-p6 with phosphatidyl choline liposomes Chemical Physics Letters, 401 (1-3). pp. 185-188. ISSN 0009-2614
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00092...
Related URL: http://dx.doi.org/10.1016/j.cplett.2004.11.051
Abstract
The pH dependent binding of the photosensitizer chlorin-p6 with phosphatidyl choline liposomes was investigated at varying lipid:drug molar ratio. At pH 5.0, substantial changes in the absorption and emission spectra of the drug were observed when liposomes were added. At higher pH these changes became progressively smaller and observable only at higher liposomes concentrations. Studies carried out on fluorescence emission lifetimes as well as quenching of fluorescence with KI suggest that at pH 5.0 the drug localizes in the central region of lipid bilayer and for pH 6.0 and higher the drug binds closer to the liposome interface.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 22262 |
| Deposited On: | 23 Nov 2010 08:37 |
| Last Modified: | 02 Jun 2011 06:56 |
Repository Staff Only: item control page
