Dey, Debleena ; Basu, Dipanjan ; Roy, Sib Sankar ; Bandyopadhyay, Arun ; Bhattacharya, Samir (2006) Involvement of novel PKC isoforms in FFA induced defects in insulin signaling Molecular and Cellular Endocrinology, 246 (1-2). pp. 60-64. ISSN 0303-7207
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S03037...
Related URL: http://dx.doi.org/10.1016/j.mce.2005.12.014
Abstract
Involvement of novel PKCs (nPKCs) in the negative regulation of insulin-signaling pathway is a current interest of many workers investigating the cause for insulin resistance and type 2 diabetes. Free fatty acids (FFAs) are recently shown to be the major players in inducing insulin resistance in insulin target cells. They are also found to be involved in activating nPKCs associated with the impairment of insulin sensitivity. In this overview, we describe PKC δ, θ and ε linked to the FFA induced damage of insulin-signaling molecules.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Novel PKCs; Insulin Signaling; Insulin Resistance; Free Fatty Acids; Insulin Receptor Kinase; Phosphatidylinositol-dependent Kinase1 |
| ID Code: | 21528 |
| Deposited On: | 22 Nov 2010 06:51 |
| Last Modified: | 21 Jan 2011 04:14 |
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