Enhanced decarbamoylation of D(-)-N-carbamoyl phenyl glycine by its interfacial solubilization under micellar conditions

Jha, B. K. ; Chhatre, A. S. ; Kulkarni, B. D. ; Joshi, R. A. ; Joshi, R. R. ; Kalkote, U. R. (1994) Enhanced decarbamoylation of D(-)-N-carbamoyl phenyl glycine by its interfacial solubilization under micellar conditions Journal of Colloid and Interface Science, 163 (1). pp. 1-9. ISSN 0021-9797

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00219...

Related URL: http://dx.doi.org/10.1006/jcis.1994.1074

Abstract

D(-)-N-carbamoyl phenyl glycine is solubilized in the micellar/microemulsion solution of dilute sulfuric acid using sodium dodecyl sulfate (SDS) as surfactant and treated with sodium nitrite (limiting component) to produce quantitative yield of D(-)-phenyl glycine, an important drug intermediate. The solubilization, phase behavior, and reaction product distributions are analyzed to explain the interfacial phenomena involved.

Item Type:Article
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ID Code:17349
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