Madesh, Muniswamy ; Ramachandran, Anup ; Balasubramanian, K. A. (1999) Nitric oxide prevents anoxia-induced apoptosis in colonic HT29 cells Archives of Biochemistry and Biophysics, 366 (2). pp. 240-248. ISSN 0003-9861
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00039...
Related URL: http://dx.doi.org/10.1006/abbi.1999.1185
Abstract
Apoptosis is a critical determinant of tissue mass homeostasis and may play a role in carcinogenesis. The aim of the present study was to investigate anoxia-induced cell death in colon-derived HT29 cells and the effect of nitric oxide on this phenomenon. It was found that HT29 cells subjected to anoxia undergo apoptosis in a time dependent manner, as determined by DNA fragmentation and Hoechst-33258 dye staining. Cytochrome c release from mitochondria to cytosol is a key step in this process and this release precedes DNA fragmentation. NO inhibits anoxia induced apoptosis in these cells by inhibiting the release of cytochrome c and thus may play a role in modulating the apoptotic cell death of colon-derived epithelial cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Nitric Oxide; Apoptosis; Cytochrome c; HT29 Cells |
| ID Code: | 1462 |
| Deposited On: | 05 Oct 2010 12:28 |
| Last Modified: | 14 May 2011 04:54 |
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