Expedient Synthesis of Large-Ringtrans-Enamide Macrolides by CuI-Mediated Intramolecular Coupling of Vinyl Iodide with Amide: Total Synthesis of Palmyrolide A

Yadav, Jhillu Singh ; Suresh, Borra ; Srihari, Pabbaraja (2016) Expedient Synthesis of Large-Ringtrans-Enamide Macrolides by CuI-Mediated Intramolecular Coupling of Vinyl Iodide with Amide: Total Synthesis of Palmyrolide A European Journal of Organic Chemistry, 2016 (14). pp. 2509-2513. ISSN 1434-193X

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Official URL: http://doi.org/10.1002/Ejoc.201600325

Related URL: http://dx.doi.org/10.1002/Ejoc.201600325

Abstract

An improved method to synthesize enamide-containing macrolides by copper-mediated intramolecular vinylation of amides is described. The method was applied to access several large-ring macrolides, including neuroactive natural product palmyrolide A, desmethyl palmyrolide A, and homologated sanctolide A.

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ID Code:135706
Deposited On:10 Aug 2023 10:17
Last Modified:10 Aug 2023 10:17

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