Reddy, Dodda Vasudeva ; Sabitha, Gowravaram ; Rao, Tadikamalla Prabhakar ; Yadav, Jhillu Singh (2016) Total Synthesis of Anticancer Agent EBC-23 Organic Letters, 18 (17). pp. 4202-4205. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.6b01849
Related URL: http://dx.doi.org/10.1021/acs.orglett.6b01849
Abstract
Total synthesis of spiroketal EBC-23 has been described by two divergent approaches from three simple building blocks. Gold-catalyzed cycloisomerization of alkynol and acid-mediated spirocyclization of diketalketone were successfully utilized to effect spiroketal formation. A Cu(I)-P(Cy)3-catalyzed protocol for the highly regio- and stereocontrolled hydroboration of internal propargylic alcohol was effectively applied toward the β-hydroxy ketone via vinylboronates.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 135696 |
| Deposited On: | 10 Aug 2023 08:22 |
| Last Modified: | 10 Aug 2023 08:22 |
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