Total Synthesis of Anticancer Agent EBC-23

Reddy, Dodda Vasudeva ; Sabitha, Gowravaram ; Rao, Tadikamalla Prabhakar ; Yadav, Jhillu Singh (2016) Total Synthesis of Anticancer Agent EBC-23 Organic Letters, 18 (17). pp. 4202-4205. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/acs.orglett.6b01849

Related URL: http://dx.doi.org/10.1021/acs.orglett.6b01849

Abstract

Total synthesis of spiroketal EBC-23 has been described by two divergent approaches from three simple building blocks. Gold-catalyzed cycloisomerization of alkynol and acid-mediated spirocyclization of diketalketone were successfully utilized to effect spiroketal formation. A Cu(I)-P(Cy)3-catalyzed protocol for the highly regio- and stereocontrolled hydroboration of internal propargylic alcohol was effectively applied toward the β-hydroxy ketone via vinylboronates.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:135696
Deposited On:10 Aug 2023 08:22
Last Modified:10 Aug 2023 08:22

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