Nath, Jayashree ; Chaudhuri, Mihir K. (2010) Borax: An Ecofriendly and Efficient Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones under Solvent-Free Conditions Synthetic Communications, 40 (20). pp. 2976-2982. ISSN 0039-7911
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Official URL: http://doi.org/10.1080/00397910903341163
Related URL: http://dx.doi.org/10.1080/00397910903341163
Abstract
Borax in the presence of a very small amount of 5 M sulfuric acid efficiently catalyses the three-component condensation of an aldehyde, β-ketoester, and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or 3,4-dihydropyrimidin-2(1H)-thiones in good to excellent yields under solvent-free conditions at 80 °C. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yield, short reaction time (1–2 h), easy workup, and no use of volatile organic solvent.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Informa UK Limited |
| Keywords: | Biginelli reactionborax3;4-dihydropyrimidin-2(1H)-onessolvent free |
| ID Code: | 134051 |
| Deposited On: | 03 Jan 2023 09:03 |
| Last Modified: | 03 Jan 2023 09:03 |
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