Chandrasekhar, Srivari ; Mahipal, Bodugam ; Kavitha, Mitta (2009) Toward Tubulysin: Gram-Scale Synthesis of Tubuvaline-Tubuphenylalanine Fragment The Journal of Organic Chemistry, 74 (24). pp. 9531-9534. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/jo9015503
Related URL: http://dx.doi.org/10.1021/jo9015503
Abstract
A practical and stereoselective synthesis of the tubuvaline-tubuphenylalanine (Tuv-Tup) fragment of tubulysin is achieved involving the opening of aziridine, crucial MacMillan α-hydroxylation on both fragments, and an epoxide-opening reaction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 131425 |
| Deposited On: | 06 Dec 2022 12:59 |
| Last Modified: | 06 Dec 2022 12:59 |
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