Kallepu, Shivakrishna ; Kavitha, Minnapuram ; Yeeravalli, Ragini ; Manupati, Kanakaraju ; Jadav, Surender Singh ; Das, Amitava ; Mainkar, Prathama S. ; Chandrasekhar, Srivari (2018) Total Synthesis of Desmethyl Jahanyne and Its Lipo-Tetrapeptide Conjugates Derived from Parent Skeleton as BCL-2-Mediated Apoptosis-Inducing Agents ACS Omega, 3 (1). pp. 63-75. ISSN 2470-1343
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Official URL: http://doi.org/10.1021/acsomega.7b01634
Related URL: http://dx.doi.org/10.1021/acsomega.7b01634
Abstract
The total synthesis of highly potent and scarcely available marine natural product (−)-jahanyne was attempted resulting in a solution-phase synthesis of pruned versions with comparable activity. A simple and facile synthetic route was employed for the preparation of pruned congeners and would be scalable. The lipophilic tail of the natural product was synthesized from R-(+)-citronellol, utilizing easily available chemicals. All the synthesized compounds were screened for apoptotic activity against a panel of cell lines. These compounds depicted marked binding to B cell lymphoma 2 till 50 °C in cellular thermal shift analysis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 131297 |
| Deposited On: | 06 Dec 2022 09:19 |
| Last Modified: | 06 Dec 2022 09:19 |
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