Shekhar, Chandra ; Nasam, Rajesh ; Paipuri, Siva Ramakrishna ; Kumar, Prakash ; Nayani, Kiranmai ; Pabbaraja, Srihari ; Mainkar, Prathama S. ; Chandrasekhar, Srivari (2022) Total synthesis of antiviral drug, nirmatrelvir (PF-07321332) Tetrahedron Chem, 4 . p. 100033. ISSN 2666951X
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Official URL: http://doi.org/10.1016/j.tchem.2022.100033
Related URL: http://dx.doi.org/10.1016/j.tchem.2022.100033
Abstract
The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has swiftly led to public health crisis worldwide. Hence vaccines and antiviral therapeutics are an important part of the healthcare response to combat the ongoing threat by COVID-19. Here, we report an efficient synthesis of nirmatrelvir (PF-07321332), an orally active SARS-CoV-2 main protease inhibitor.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Inc |
| Keywords: | Antiviral drug;COVID-19;Peptide;Protein mimetic;Amino acid;Peptide coupling;Cyclopropanation |
| ID Code: | 131261 |
| Deposited On: | 06 Dec 2022 08:28 |
| Last Modified: | 06 Dec 2022 08:28 |
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