Mal, Arindam ; Mishra, Rakesh K. ; Praveen, Vakayil K. ; Khayum, M. Abdul ; Banerjee, Rahul ; Ajayaghosh, Ayyappanpillai (2018) Supramolecular Reassembly of Self‐Exfoliated Ionic Covalent Organic Nanosheets for Label‐Free Detection of Double‐Stranded DNA Angewandte Chemie International Edition, 57 (28). pp. 8443-8447. ISSN 1433-7851
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Official URL: http://doi.org/10.1002/anie.201801352
Related URL: http://dx.doi.org/10.1002/anie.201801352
Abstract
Ionic covalent organic nanosheets (iCONs), a member of the two-dimensional (2D) nanomaterials family, offer a unique functional platform for a wide range of applications. Herein, we explore the potential of an ethidium bromide (EB)-based covalent organic framework (EB-TFP) that self-exfoliates in water resulting in 2D ionic covalent organic nanosheets (EB-TFP-iCONs) for the selective detection of double-stranded DNA (dsDNA). In an aqueous medium, the self-exfoliated EB-TFP-iCONs reassemble in the presence of dsDNA resulting in hybrid EB-TFP-iCONs-DNA crystalline nanosheets with enhanced fluorescence at 600 nm. Detailed steady-state and time-resolved emission studies revealed that the reassembly phenomenon was highly selective for dsDNA when compared to single-stranded DNA (ssDNA), which allowed us to use the EB-TFP-iCONs as a 2D fluorescent platform for the label-free detection of complementary DNA strands.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
ID Code: | 129964 |
Deposited On: | 28 Nov 2022 11:32 |
Last Modified: | 28 Nov 2022 11:32 |
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