Gaur, Priyanka ; Misra, Ramnath ; Aggarwal, Amita (2015) Natural killer cell and gamma delta T cell alterations in enthesitis related arthritis category of juvenile idiopathic arthritis Clinical Immunology, 161 (2). pp. 163-169. ISSN 15216616
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Official URL: http://doi.org/10.1016/j.clim.2015.07.012
Related URL: http://dx.doi.org/10.1016/j.clim.2015.07.012
Abstract
Enthesitis related arthritis (ERA) is associated with increased frequency of Th17 cells and synovial fluid (SF) IL-17 levels. Natural killer (NK) and gamma delta T cells have been recently shown to produce IL-17, thus we studied the NK and gamma delta-T cells in peripheral blood (PB) of 50 ERA, 16 other JIA patients and 19 healthy controls. We have analyzed the frequency of NK (total, CD56dim, CD56bright) and gamma delta-T cells, perforin and KIR3DL1/2 expression on NK cells and IL-17 and IFN-gamma production by them using flow cytometry. ERA patients had more NK cells with reduced perforin expression and IFN-gamma production but increased KIR3DL1/2 expression and IL-17 production as compared to controls. Also IL-17 producing gamma delta-T were increased in PB of ERA patients. Paired SF samples had NK cells with reduced perforin and KIR3DL expression. Thus increased NK and gamma delta-T cells may contribute to the inflammation in ERA by producing IL-17.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Inc. |
Keywords: | Childhood arthritis; Inflammation; Innate immune cells; Killer immunoglobulin-like receptors; Perforin; Synovial fluid |
ID Code: | 129416 |
Deposited On: | 23 Nov 2022 10:32 |
Last Modified: | 23 Nov 2022 10:32 |
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