Adhya, Samit ; Mahato, Biraj ; Jash, Sukanta ; Koley, Sandip ; Dhar, Gunjan ; Chowdhury, Tapas (2011) Mitochondrial gene therapy: The tortuous path from bench to bedside Mitochondrion, 11 (6). pp. 839-844. ISSN 15677249
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Official URL: http://doi.org/10.1016/j.mito.2011.06.003
Related URL: http://dx.doi.org/10.1016/j.mito.2011.06.003
Abstract
The association of mitochondrial dysfunction with a variety of human diseases and disabilities has been documented. Mitochondrial gene therapy (MGT) seeks to correct the genetic defect in mitochondrial DNA. For successful MGT, an appreciation of the nature of the dysfunction and of the complexities of mitochondrial disease is necessary. This review summarizes the current status of various MGT protocols described in the literature. Although there are many technical difficulties to be overcome, there are indications that some of them will find clinical applications in the near future.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Mitochondria, Dysfunction, Gene therapy |
| ID Code: | 129202 |
| Deposited On: | 22 Nov 2022 10:53 |
| Last Modified: | 22 Nov 2022 10:53 |
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