Exacerbation of Vascular Endothelial Injury in the Generalized Shwartzman Reaction by the Administration of Anti-E-Selectin Antibody

Koide, Naoki ; Kato, Yutaka ; Sugiyama, Tsuyoshi ; Chakravortty, Dipshika ; Mu, Mya Mya ; Yoshida, Tomoaki ; Yokochi, Takashi (2013) Exacerbation of Vascular Endothelial Injury in the Generalized Shwartzman Reaction by the Administration of Anti-E-Selectin Antibody Microbiology and Immunology, 44 (3). pp. 197-200. ISSN 0385-5600

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Official URL: http://doi.org/10.1111/j.1348-0421.2000.tb02483.x

Related URL: http://dx.doi.org/10.1111/j.1348-0421.2000.tb02483.x

Abstract

Previously, we reported that the consecutive administration of lipopolysaccharide (LPS) into LPS-sensitized mice for the generalized Shwartzman reaction (GSR) induced systemic injury of vascular endothelial cells. The aim of this study was to investigate the participation of vascular adhesion molecules in the vascular endothelial injury of GSR. The administration of anti-E-selectin antibody in GSR-induced mice resulted in massive apoptosis of vascular endothelial cells and congestion in blood vessels. Further, marked hemorrhage was found in the pulmonary alveoli of those mice. GSR, especially lung injury, was definitely exacerbated by the administration of anti-E-selectin antibody. On the other hand, the administration of anti-VCAM-1 antibody did not induce such injury of vascular endothelial cells. The possible role of E-selectin in the exacerbation of vascular endothelial injury in GSR is discussed.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons, Inc.
Keywords:Endotoxin; Lipopolysaccharide; DIC; Vascular Endothelial Cell; E-selectin; Anti-e-selectin Antibody.
ID Code:118465
Deposited On:21 May 2021 09:09
Last Modified:02 Feb 2023 05:51

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