Raichur, Ashok ; Thomas, M ; Radhakrishnan, K ; Gnanadhas, D ; Chakravortty, Dipshikha (2013) Intracellular delivery of doxorubicin encapsulated in novel pH-responsive chitosan/heparin nanocapsules International Journal of Nanomedicine, 8 (1). pp. 267-273. ISSN 1178-2013
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Official URL: http://doi.org/10.2147/IJN.S37737
Related URL: http://dx.doi.org/10.2147/IJN.S37737
Abstract
A novel polyelectrolyte nanocapsule system composed of biopolymers, chitosan and heparin has been fabricated by the layer-by-layer technique on silica nanoparticles followed by dissolution of the silica core. The nanocapsules were of the size range 200 ± 20 nm and loaded with the positively charged anticancer drug doxorubicin with an efficiency of 89%. The loading of the drug into the capsule happens by virtue of the pH-responsive property of the capsule wall, which is determined by the pKa of the polyelectrolytes. As the pH is varied, about 64% of the drug is released in acidic pH while 77% is released in neutral pH. The biocompatibility, efficiency of drug loading, and enhanced bioavailability of the capsule system was confirmed by MTT assay and in vivo biodistribution studies.
Item Type: | Article |
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Source: | Copyright of this article belongs to Dove Press Ltd. |
Keywords: | Drug Delivery; Layer-by-Layer; Electrostatic Interaction; Biocompatible. |
ID Code: | 118338 |
Deposited On: | 20 May 2021 10:04 |
Last Modified: | 20 May 2021 10:04 |
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