Dutta, Pradip Kumar ; Sharma, Rupali ; Kumari, Smita ; Dubey, Ravindra Dhar ; Sarkar, Sujit ; Paulraj, Justin ; Vijaykumar, Gonela ; Pandey, Manoj ; Sravanti, L. ; Samarla, Mallik ; Das, Hari Sankar ; Yashpal, Yashpal ; B., Heeralal ; Goyal, Ravinder ; Gupta, Nimish ; Mandal, Swadhin K. ; Sengupta, Aniruddha ; Sarkar, Arindam (2019) A safe and efficacious Pt(ii) anticancer prodrug: design, synthesis, in vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition Chemical Communications, 55 (12). pp. 1718-1721. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/C8CC06586A
Related URL: http://dx.doi.org/10.1039/C8CC06586A
Abstract
Diaminocyclohexane-Pt(II)-phenalenyl complexes (1 and 2) showed an appropriate balance between efficacy and toxicity. Compound 2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 118268 |
| Deposited On: | 19 May 2021 12:31 |
| Last Modified: | 19 May 2021 12:31 |
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