Pal, Chiranjib ; Raha, Mousumi ; Basu, Anirban ; Roy, Keshab Chandra ; Gupta, Anasuya ; Ghosh, Monidipa ; Sahu, Niranjan Prasad ; Banerjee, Sukdeb ; Mandal, Nirup Bikash ; Bandyopadhyay, Santu (2002) Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters Antimicrobial Agents and Chemotherapy, 46 (1). pp. 259-261. ISSN 0066-4804
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Official URL: http://doi.org/10.1128/AAC.46.1.259-261.2002
Related URL: http://dx.doi.org/10.1128/AAC.46.1.259-261.2002
Abstract
2-(2″-Dichloroacetamidobenzyl)-3-(3′-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani-infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia from the livers and spleens was noticed when infected animals received indolylquinoline derivative A plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive therapy for leishmaniasis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| Keywords: | Antimony Sodium Gluconate; Antiprotozoal Agents; Indoles; Leishmaniasis Visceral; Quinolines. |
| ID Code: | 115691 |
| Deposited On: | 18 Mar 2021 04:52 |
| Last Modified: | 18 Mar 2021 04:52 |
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