Kumar, Vaijayanti ; Pallan, Pradeep S. ; Meena, ; Ganesh, Krishna N. (2001) Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid Organic Letters, 3 (9). pp. 1269-1272. ISSN 1523-7060
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Official URL: http://pubs.acs.org/doi/abs/10.1021/ol0069655
Related URL: http://dx.doi.org/10.1021/ol0069655
Abstract
Synthesis of pyrrolidine-based chiral positively charged DNA analogues is reported. The synthesis of (2S,4S) and (2R,4R) thymin-1-ylpyrrolidine-N-acetic acid, its site specific incorporation in PNA:DNA chimera and PNA, and the study of their binding properties with complementary DNA/RNA sequences is presented.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 10798 |
| Deposited On: | 09 Nov 2010 04:52 |
| Last Modified: | 31 May 2011 09:42 |
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