Synthesis and characterization of naphthalimide-containing peptide nucleic acid

Ikeda, Hisafumi ; Nakamura, Yushin ; Saito, Isao (2002) Synthesis and characterization of naphthalimide-containing peptide nucleic acid Tetrahedron Letters, 43 (32). pp. 5525-5528. ISSN 0040-4039

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/S0040-4039(02)01164-4

Abstract

Naphthalimide-containing PNA monomer unit 6 was synthesized for the preparation of PNAs containing a naphthalimide chromophore (NPNA). PNA oligomers were purified by reversed-phase HPLC and characterized by MALDI-TOF MS and UV spectra. Thermodynamic analyses revealed that the PNA oligomer containing a naphthalimide moiety at the amino terminal stabilizes PNA–DNA hybrids.

Item Type:Article
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ID Code:105641
Deposited On:21 Dec 2017 12:04
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