Mishra, Satish ; Chawla, Deepak ; Agarwal, Ramesh ; Deorari, Ashok Kumar ; Paul, Vinod Kumar (2010) Transcutaneous bilirubin levels in healthy term and late preterm Indian neonates Indian Journal of Pediatrics, 77 (1). pp. 45-50. ISSN 0019-5456
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Official URL: http://link.springer.com/article/10.1007%2Fs12098-...
Related URL: http://dx.doi.org/10.1007/s12098-010-0007-3
Abstract
Objective: To provide normative data for transcutaneous bilirubin (TcB) measurements in healthy term and late-preterm Indian neonates during first 72 h of age using a multiwavelength reflectance transcutaneous bilimeter. Methods: TcB measurements were performed in healthy neonates (gestation 35 wk), in a well-baby ward, using a multiwavelength transcutaneous bilimeter (BiliCheck®, SpectRx Inc, Norcross, GA). Age-specific percentiles values for each 6-h epoch starting at 0 h of age were calculated and an age-specific TcB nomogram was developed using different percentile values. Diagnostic ability of each percentile curve for prediction of hyperbilirubinemia, defined as requirement of phototherapy, was calculated. Results: We performed 925 TcB measurements on 625 healthy newborn infants (gestation: 35 to 41 wk; age: 0 to 72 h; mean birth weight: 2808±437 g). TcB increased in a linear manner with maximum rate of rise observed during first 24 h of age (50th percentile: 0.22 mg/dL/h). 50th percentile curve of age-specific TcB nomogram had high negative predictive value (99.8%) and acceptable positive predictive value (16.4%) for prediction of hyperbilirubinemia. Conclusion: We provided age-specific nomogram of TcB for first 72 h of age in healthy term and late-preterm Indian neonates. Percentile curves and rate of rise in TcB may help in identification of neonates at low-risk of development of hyperbilirubinemia facilitating their safer discharge from the hospital. Diagnostic utility of this nomogram for predicting hyperbilirubinemia needs to be tested in a separate validation cohort.
Item Type: | Article |
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Source: | Copyright of this article belongs to Springer Verlag. |
Keywords: | Hyperbilirubinemia; Neonates; Transcutaneous Bilirubin (TcB); Nomogram |
ID Code: | 103985 |
Deposited On: | 08 Dec 2017 09:34 |
Last Modified: | 08 Dec 2017 09:34 |
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