eprintid: 73352
rev_number: 15
eprint_status: archive
userid: 9
dir: disk0/00/07/33/52
datestamp: 2011-12-03 12:17:30
lastmod: 2013-02-12 11:31:11
status_changed: 2011-12-03 12:17:30
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Abdulla, Mahmood Ameen
creators_name: Ahmed, Ikhlak
creators_name: Assawamakin, Anunchai
creators_name: Bhak, Jong
creators_name: Brahmachari, Samir K.
creators_name: Calacal, Gayvelline C.
creators_name: Chaurasia, Amit
creators_name: Chen, Chien-Hsiun
creators_name: Chen, Jieming
creators_name: Chen, Yuan-Tsong
creators_name: . . . ; Majumder, P. P.; . . .  (The HUGO Pan-Asian SNP Consortium)
title: Mapping human genetic diversity in Asia
ispublished: pub
subjects: QL
divisions: Animal_Plant
full_text_status: none
note: Copyright of this article belongs to American Association for the Advancement of Science.
abstract: Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
date: 2009-12-11
date_type: published
publication: Science
volume: 326
number: 5959
publisher: American Association for the Advancement of Science
pagerange: 1541-1545
id_number: 10.1126/science.1177074
refereed: TRUE
issn: 0036-8075
official_url: http://www.sciencemag.org/content/326/5959/1541.abstract?sid=c764794b-4362-469e-b11d-ba9243451d50
fellow_name: Majumder, Partha Pratim
citation:   Abdulla, Mahmood Ameen ; Ahmed, Ikhlak ; Assawamakin, Anunchai ; Bhak, Jong ; Brahmachari, Samir K. ; Calacal, Gayvelline C. ; Chaurasia, Amit ; Chen, Chien-Hsiun ; Chen, Jieming ; Chen, Yuan-Tsong ; . . . ; Majumder, P. P.; . . . (The HUGO Pan-Asian SNP Consortium)  (2009) Mapping human genetic diversity in Asia  Science, 326  (5959).   pp. 1541-1545.  ISSN 0036-8075