%X Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
%A Mahmood Ameen Abdulla
%A Ikhlak Ahmed
%A Anunchai Assawamakin
%A Jong Bhak
%A Samir K. Brahmachari
%A Gayvelline C. Calacal
%A Amit Chaurasia
%A Chien-Hsiun Chen
%A Jieming Chen
%A Yuan-Tsong Chen
%A P. P.; . . .  (The HUGO Pan-Asian SNP Consortium) . . . ; Majumder
%L iaseprints73352
%R 10.1126/science.1177074
%I American Association for the Advancement of Science
%D 2009
%V 326
%N 5959
%J Science
%T Mapping human genetic diversity in Asia
%O Copyright of this article belongs to American Association for the Advancement of Science.
%P 1541-1545