TY  - JOUR
Y1  - 2009/12/11/
TI  - Mapping human genetic diversity in Asia
SN  - 0036-8075
AV  - none
A1  - Abdulla, Mahmood Ameen
A1  - Ahmed, Ikhlak
A1  - Assawamakin, Anunchai
A1  - Bhak, Jong
A1  - Brahmachari, Samir K.
A1  - Calacal, Gayvelline C.
A1  - Chaurasia, Amit
A1  - Chen, Chien-Hsiun
A1  - Chen, Jieming
A1  - Chen, Yuan-Tsong
A1  - . . . ; Majumder, P. P.; . . .  (The HUGO Pan-Asian SNP Consortium)
N1  - Copyright of this article belongs to American Association for the Advancement of Science.
VL  - 326
ID  - iaseprints73352
EP  - 1545
SP  - 1541
UR  - http://www.sciencemag.org/content/326/5959/1541.abstract?sid=c764794b-4362-469e-b11d-ba9243451d50
PB  - American Association for the Advancement of Science
IS  - 5959
JF  - Science
N2  - Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
ER  -