%0 Journal Article
%@ 0036-8075
%A Abdulla, Mahmood Ameen
%A Ahmed, Ikhlak
%A Assawamakin, Anunchai
%A Bhak, Jong
%A Brahmachari, Samir K.
%A Calacal, Gayvelline C.
%A Chaurasia, Amit
%A Chen, Chien-Hsiun
%A Chen, Jieming
%A Chen, Yuan-Tsong
%A . . . ; Majumder, P. P.; . . .  (The HUGO Pan-Asian SNP Consortium)
%D 2009
%F iaseprints:73352
%I American Association for the Advancement of Science
%J Science
%N 5959
%P 1541-1545
%T Mapping human genetic diversity in Asia
%U http://repository.ias.ac.in/73352/
%V 326
%X Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
%Z Copyright of this article belongs to American Association for the Advancement of Science.