http://repository.ias.ac.in/id/eprint/73352 2013-02-12T11:31:11Z info:eu-repo/semantics/descriptiveMetadata http://repository.ias.ac.in/73352/ Mapping human genetic diversity in Asia Abdulla, Mahmood Ameen Ahmed, Ikhlak Assawamakin, Anunchai Bhak, Jong Brahmachari, Samir K. Calacal, Gayvelline C. Chaurasia, Amit Chen, Chien-Hsiun Chen, Jieming Chen, Yuan-Tsong . . . ; Majumder, P. P.; . . . (The HUGO Pan-Asian SNP Consortium) QL Zoology Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations. American Association for the Advancement of Science 2009-12-11 Article PeerReviewed Abdulla, Mahmood Ameen ; Ahmed, Ikhlak ; Assawamakin, Anunchai ; Bhak, Jong ; Brahmachari, Samir K. ; Calacal, Gayvelline C. ; Chaurasia, Amit ; Chen, Chien-Hsiun ; Chen, Jieming ; Chen, Yuan-Tsong ; . . . ; Majumder, P. P.; . . . (The HUGO Pan-Asian SNP Consortium) (2009) Mapping human genetic diversity in Asia Science, 326 (5959). pp. 1541-1545. ISSN 0036-8075 http://www.sciencemag.org/content/326/5959/1541.abstract?sid=c764794b-4362-469e-b11d-ba9243451d50 10.1126/science.1177074 info:eu-repo/semantics/humanStartPage