relation: http://repository.ias.ac.in/73352/
title: Mapping human genetic diversity in Asia
creator: Abdulla, Mahmood Ameen
creator: Ahmed, Ikhlak
creator: Assawamakin, Anunchai
creator: Bhak, Jong
creator: Brahmachari, Samir K.
creator: Calacal, Gayvelline C.
creator: Chaurasia, Amit
creator: Chen, Chien-Hsiun
creator: Chen, Jieming
creator: Chen, Yuan-Tsong
creator: . . . ; Majumder, P. P.; . . .  (The HUGO Pan-Asian SNP Consortium)
subject: QL Zoology
description: Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
publisher: American Association for the Advancement of Science
date: 2009-12-11
type: Article
type: PeerReviewed
identifier:   Abdulla, Mahmood Ameen ; Ahmed, Ikhlak ; Assawamakin, Anunchai ; Bhak, Jong ; Brahmachari, Samir K. ; Calacal, Gayvelline C. ; Chaurasia, Amit ; Chen, Chien-Hsiun ; Chen, Jieming ; Chen, Yuan-Tsong ; . . . ; Majumder, P. P.; . . . (The HUGO Pan-Asian SNP Consortium)  (2009) Mapping human genetic diversity in Asia  Science, 326  (5959).   pp. 1541-1545.  ISSN 0036-8075     
relation: http://www.sciencemag.org/content/326/5959/1541.abstract?sid=c764794b-4362-469e-b11d-ba9243451d50
relation: 10.1126/science.1177074