Human red blood cell membrane damage by endosulfan

Daniel, Clive Sunil ; Agarwal, Sarita ; Agarwal, Shyam S. (1986) Human red blood cell membrane damage by endosulfan Toxicology Letters, 32 (1-2). pp. 113-118. ISSN 0378-4274

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Endosulfan is a chlorinated hydrocarbon insecticide. Its in vitro toxicity on human red blood cell membrane was studied by staining with a fluorochrome dye, merocyanine-540 (MC-540) and Scanning Electron muscopy (SEM). At a concentration of 0.001μg/ml(1 ppb) endosulfan was found to damage human red cell membranes as demonstrated by fluorescence of 30-50% of red cells on staining with MC-540. This was supported by the finding of crenation and threading of red blood cells under SEM. At concentration of 1μg/ml (1 ppm) the cells were markedly damaged.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Endosulfan Toxicity; Scanning Electron Muscopy; Merocyanine-540
ID Code:81
Deposited On:16 Sep 2010 10:56
Last Modified:12 May 2011 04:08

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